Laboratory of Biomolecular Homeostasis & Resilience
Welcome to the Joshi Lab!
We are a curiosity- and innovation-driven lab at Georgetown University Medical Center investigating how biomolecular homeostasis changes during aging and becomes dysregulated in neurodegenerative diseases. Our research combines biophysical, biochemical, and machine learning approaches to uncover fundamental mechanisms in cellular and organismal biology, with a particular focus on understanding the stochastic nature of protein misfolding in aging.
Through innovative quantitative tools and techniques, we study metabolite-protein interactions that drive cellular and molecular processes underlying aging. Our long-term vision is to create a comprehensive map of the protein-metabolite structural-ome that underlies selective vulnerability in disease, helping us understand what determines healthy versus pathological cellular fates.
Located in the heart of Washington DC, a vibrant global science hub, we embrace fresh perspectives and welcome researchers from all backgrounds and cultures to join us in this exciting journey of scientific discovery and innovation.
We pursue fundamental molecular discoveries that push scientific boundaries and accelerate therapeutic breakthroughs.
Our lab culture thrives through collaboration, respect and enabling personal growth.
Lab News
September 2025
Joe Wang joins the lab for his PhD rotation. Welcome Joe! 🎉
Priyanka presents the lab and our protein engineering work with Mukul at the ISM Day 2025.
August 2025
Pranjal Madhav Dhat completes her Master thesis in Bioinformatics and graduates from the lab! Congratulations Pranjal! 👏🏼
Mukul Sherekar joins the lab as a Research Associate. Welcome Mukul! 🎉
Sonsoles presented a poster at the Brixen Proteomics Summer School in Italy, for which she received a Travel Award. Congrats Sonsoles! 🥳 Sonsoles also officially begins her PhD in the lab!
Priyanka attended the Military Health System Research Symposium (MHSRS) 2025 with X10e, to present our work and further our collaborations with USUHS and MTBI2.
July 2025
We wrapped up our AI-BTO seedling phase grant in collaboration with X10e and presented our work at DARPA.
June 2025
Priyanka visits CERM, Italy and visits the labs of Roberta Pieratelli and Isabella Felli.
We are busy ramping up the setup of our new in-lab instruments: Cytation 10 Confocal Imaging Reader , CLARIOstar Plus Microplate Reader and NGC Quest 10 Plus Chromatography System.
May 2025
Rachel and Sonsoles present a poster at the CNIR Symposium on their rotation project!
Priyanka gives an invited lecture in the Soft Matter Seminar series at Institute for Soft Matter Synthesis & Metrology at Georgetown.
April 2025
Priyanka gives an invited seminar at the United States Military Academy Westpoint on environmental exposures as drivers of protein misfolding in neurodegenerative diseases.
Kyndall presents a poster at Systems Medicine Spring 2025 presentations at Georgetown.
January 2025
Rachel joins the lab for her PhD rotation. Welcome Rachel!
Kyndall joins the lab for her Masters thesis. Welcome Kyndall!
December 2024
The lab had its first official Christmas party before the holidays! 🎄
Priyanka gave a short presentation at the AI-BTO pitch day.
November 2024
Priyanka presents at the 3rd Annual Partners in Research Innovation Showcase at Georgetown University.
Pranjal and Jash join the lab. Welcome!
October 2024
The lab joins the Faculty Entrepreneurship Academy, an initiative developed by the Georgetown Office of Technology Commercialization (OTC) and part of Georgetown Tech Ventures (GTV) program.
Deeksha Surisetty joins the lab as our Lab Manager! Welcome Deeksha!
September 2024
Zheng Ji joins the lab for his Masters thesis. Welcome Zheng!
Sonsoles Liera Viegas joins the lab for her PhD rotation. Welcome Sonsoles!
Priyanka presents at the BioEntrepreneurship & Innovation (BEI) program, University of Zurich, as an Expert in Residence.
August 2024
Thomas Leiding visits the lab from Sweden to install our first instrument - The Labbot. We are thrilled that The Hoya covered this inaugural event in our lab. We can’t wait to make new discoveries using the Labbot!
Priyanka gave a presentation of the lab’s research and vision at the Leading Edge Retreat at Cold Spring Harbor Laboratory, NY.
The Joshi lab opens in the Department of Biochemistry and Molecular & Cellular Biology in the historic Med Dent building at Georgetown University Medical Center 🎉