Laboratory of Biomolecular Homeostasis & Resilience

Welcome to the Joshi Lab!

We are a curiosity- and innovation-driven lab at Georgetown University Medical Center investigating how biomolecular homeostasis changes during aging and becomes dysregulated in neurodegenerative diseases. Our research combines biophysical, biochemical, and machine learning approaches to uncover fundamental mechanisms in cellular and organismal biology, with a particular focus on understanding the stochastic nature of protein misfolding in aging.

Through innovative quantitative tools and techniques, we study metabolite-protein interactions that drive cellular and molecular processes underlying aging. Our long-term vision is to create a comprehensive map of the protein-metabolite structural-ome that underlies selective vulnerability in disease, helping us understand what determines healthy versus pathological cellular fates.

Located in the heart of Washington DC, a vibrant global science hub, we embrace fresh perspectives and welcome researchers from all backgrounds and cultures to join us in this exciting journey of scientific discovery and innovation.

We believe that fundamental discoveries at the molecular level provide the foundation for therapeutic innovations.

Our lab culture thrives through collaboration, respect and enabling personal growth.

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Lab News

May 2025

  • Rachel and Sonsoles present a poster at the CNIR Symposium on their rotation project!

  • Priyanka gives an invited lecture in the Soft Matter Seminar series at Institute for Soft Matter Synthesis & Metrology at Georgetown.

April 2025

  • Priyanka gives an invited seminar at the United States Military Academy Westpoint on environmental exposures as drivers of protein misfolding in neurodegenerative diseases.

  • Kyndall presents a poster at Systems Medicine Spring 2025 presentations at Georgetown.

January 2025

  • Rachel joins the lab for her PhD rotation. Welcome Rachel!

  • Kyndall joins the lab for her Masters thesis. Welcome Kyndall!

December 2024

  • The lab had its first official Christmas party before the holidays! 🎄

  • Priyanka gave a short presentation at the AI-BTO pitch day.

November 2024

  • Priyanka presents at the 3rd Annual Partners in Research Innovation Showcase at Georgetown University.

  • Pranjal and Jash join the lab. Welcome!

October 2024

  • The lab joins the Faculty Entrepreneurship Academy, an initiative developed by the Georgetown Office of Technology Commercialization (OTC) and part of Georgetown Tech Ventures (GTV) program.

  • Deeksha Surisetty joins the lab as our Lab Manager! Welcome Deeksha!

September 2024

  • Zheng Ji joins the lab for his Masters thesis. Welcome Zheng!

  • Sonsoles Liera Viegas joins the lab for her PhD rotation. Welcome Sonsoles!

  • Priyanka presents at the BioEntrepreneurship & Innovation (BEI) program, University of Zurich, as an Expert in Residence.

August 2024

  • Thomas Leiding visits the lab from Sweden to install our first instrument - The Labbot. We are thrilled that The Hoya covered this inaugural event in our lab. We can’t wait to make new discoveries using the Labbot!

  • Priyanka gave a presentation of the lab’s research and vision at the Leading Edge Retreat at Cold Spring Harbor Laboratory, NY.

  • The Joshi lab opens in the Department of Biochemistry and Molecular & Cellular Biology in the historic Med Dent building at Georgetown University Medical Center 🎉